Induction of Oct3/4 during direct reprogramming of dental pulp cells
نویسندگان
چکیده
منابع مشابه
Induction of Oct3/4 during direct reprogramming of dental pulp cells
We previously reported the direct reprogramming of dental pulp cells to insulin-producing cells. Hence, the potential for transdifferentiation of dental pulp cells to cells of a developmentally unrelated lineage was verified. In the current study, we evaluated the multipotential plasticity of cells during the reprogramming process by examining the expression of the pluripotent stem cell markers...
متن کاملStem Cells of the Dental Pulp
Dental Pulp Stem Cells (DPSCs) can be found within the cell rich zone of dental pulp. These stem cells, under specific stimuli, differentiate into many cell types which have wide therapeutic applications. The dental stem cells are derived from both deciduous and permanent teeth. The viable dental stem cells are very simple to collect, without any mortality and morbidity. Dental pulp stem c...
متن کاملTransdifferentiation of Human Dental Pulp Stem Cells Into Oligoprogenitor Cells
Introduction: The nerve fibers in central nervous system are surrounded by myelin sheet which is formed by oligodendrocytes. Cell therapy based on oligodendrocytes and their precursors transplantation can hold a promising alternative treatment for myelin sheet repair in demyelinating diseases. Methods: Human Dental Pulp Stem Cells (hDPSCs) are noninvasive, autologous and easy available s...
متن کاملDifferent isolation methods of dental pulp stem cells
Considering the ease of isolation and high expansion potential of pulp stem/progenitor cells isolated from wisdom and primary teeth they have been implicated as the most reliable autologous cell source in dental tissue engineering. Meanwhile, different isolation methods have remarkable impacts on the expansion potential of adult stem cells. In enzymatic digestion method extracted teeth as denta...
متن کاملAmenable epigenetic traits of dental pulp stem cells underlie high capability of xeno-free episomal reprogramming
BACKGROUND While a shift towards non-viral and animal component-free methods of generating induced pluripotent stem (iPS) cells is preferred for safer clinical applications, there is still a shortage of reliable cell sources and protocols for efficient reprogramming. METHODS Here, we show a robust episomal and xeno-free reprogramming strategy for human iPS generation from dental pulp stem cel...
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ژورنال
عنوان ژورنال: Dental, Oral and Craniofacial Research
سال: 2017
ISSN: 2058-5314
DOI: 10.15761/docr.1000229